Polynucleotides Under Eyes: Everything you need to know

Written by aesthetic content writer Catherine. Reviewed by Medical Director Dr. Sabrina Shah-Desai
Published on: June 25, 2025
Polynucleotides

Polynucleotides Under Eyes

Struggling with tired-looking under-eyes? 

You know, this is a classic. Some of us are troubled by Eyebags growing darker and hollow, or crepey scales nourish the skin there, due to time or caused by stress, lack of sleep, or good old genetics. But the ultimate must-have jargon now in skin rejuvenation is Polynucleotides Under Eyes. 

If you want to restore your under-eye area in a natural and regenerative way that doesn’t involve adding volume through traditional fillers, then this treatment may be the right fit for you. 

Let’s explore now!

What Are Polynucleotides?

Polynucleotides are purified DNA fragments, most commonly of salmon or trout origin, carrying strong regenerative and healing properties. Rather than spewing and plumping skin, once injected, they go to work repairing the skin at a cellular level, stimulating collagen synthesis, improving hydration, and enhancing tissue quality.

Unlike hyaluronic acid fillers, Polynucleotides Under the eyes stimulate the body’s natural healing processes. This is why people with Polynucleotides Under Eyes have become more popular, especially for individuals who want those long-term results instead of a quick cover-up.

Many patients interested in gentle rejuvenation sometimes combine this treatment with a natural lip filler to achieve overall facial harmony without the heaviness of traditional fillers.

Why Go for Polynucleotides Under the Eyes?

The under-eye skin is thin, tender, and very susceptible to signs of ageing like fine lines, dark circles, and puffiness. Here is why Polynucleotides Under Eyes are so great:

  • Deep hydration without the weight
  • Collagen stimulation to improve firmness and elasticity
  • Pigmentation reduction for the brightening of the under-eyes
  • Smoothing out fine lines and crepiness

It is truly for those who wish for an authentic rejuvenation rather than the volume-based effect sometimes given by overuse of traditional fillers.

Polynucleotides Under Eyes Before and After: What to Expect

Usually, the results are surprisingly never instantaneous, unlike dermal fillers, but more ongoing until late. In Polynucleotides under eyes before and after shots, one might see: 

  • Softer fine lines
  • Brighter, more even-toned skin
  • Less hollowness or puffiness
  • A healthier under-eye texture

Results will appear starting from the first or second session and get better over some weeks.

Polynucleotides Under Eyes: How Many Sessions Do You Need?

One relatively common question is:

“Polynucleotides under eyes, how many sessions will I need?”

On average, between 2 and 4 sessions are recommended, with each separated by about 2 to 3 weeks, depending on the skin’s requirements. Others may require additional sessions to begin with, and then go in for maintenance every 6 months to sustain their results.

How Long Do Polynucleotides Last Under Eyes?

Another common question: How long do polynucleotides last under the eyes?

Of course, results might vary individually. Generally, one can expect the situation to stay good for 6 to 9 months. Lifestyle, age, sun exposure, and skincare habits might affect how long a person maintains the results.

Unlike temporary fixes, you’re looking for a lift that lasts, not some kind of healthier and better-working skin that will last longer.

Who Is a Candidate for Polynucleotides Under Eyes?

  • Perfect candidates are in their late 20s to 60s and:
  • Are you dealing with tired-looking or sunken eyes
  • Have mild pigmentation or crepiness under their eyes
  • They want natural skin repair more than volume

Otherwise, the treatment may be contraindicated in pregnancy and breastfeeding and if you have active skin infections or autoimmune disorders. They should always consult a trained practitioner.

Is it Safe? What Are the Side Effects?

Yes, they’re very safe when administered by trained professionals. Since they are biocompatible, the risk of an allergic reaction is minimal. Common side effects are:

  • Mild swelling
  • Slight bruising
  • Temporary redness

Usually gone in about 24 to 48 hours, the side effects also imply very little downtime, so you could get back to your day as if nothing happened.

Can You Combine It With Other Treatments?

Most clinics pair polynucleotides with microneedling, radiofrequency, or PRP to amplify outcomes. Combining it with other facial refinements, such as a natural lip filler, can give you a general refreshed appearance without looking “done.”

If you’ve been exploring subtle tweaks like russian lip filler, it’s worth knowing that some Lip filler London clinics now also offer Polynucleotides as part of their advanced treatment menu.

Choosing the Right Clinic for Polynucleotides Under the Eyes

Since this is a delicate treatment, choosing an experienced practitioner is key. Look for a clinic that:

  • Specialises in regenerative injectables
  • Uses premium, medical-grade Polynucleotide products
  • Provides a clear consultation and follow-up plan

Don’t be lured by trend hype—make sure your professional of choice describes the science, aftercare, and timeline in detail. Precision is needed for the area under the eyes, and experience does count.

Final Thoughts

If you want a gentle yet effective way to revive your look, Polynucleotides Under Eyes might be exactly what you need. This treatment brings long-term, natural rejuvenation, from smoothing out fine lines and pigmentation to bestowing your eyes with that coveted youthful radiance.

Unsurprisingly, beauty-seekers are stepping away from the old standbys to regenerate with Polynucleotides Under Eyes—and embracing the outcome.

FAQs 

What are Polynucleotides Under Eyes?

They are purified DNA fragments that help regenerate and repair the delicate skin under your eyes, improving hydration and collagen production.

How many sessions of Polynucleotides Under Eyes are needed?

Usually, 2 to 4 sessions spaced 2-3 weeks apart are recommended for optimal results.

How long do Polynucleotides last under the eyes?

Results typically last between 6 to 9 months, depending on lifestyle and skin care.

Are Polynucleotides Under Eyes safe?

Yes, when administered by trained professionals, side effects are minimal and usually temporary.

Can Polynucleotides be combined with other treatments?

Yes, they can be combined with microneedling, PRP, or natural lip fillers for enhanced results.

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About the Author

Catherine

Expert Aesthetic Writer At Perfect Skin Studio Catherine is an expert content writer. Specialised in the aesthetic industry, she deeply understands aesthetic concepts and crafts informative and accessible content about them. At Perfect Skin Studio, Catherine's writings cover diverse skin, eyes, beauty, and aesthetic concerns, providing clear insights and practical solutions. She explores and addresses the latest trends, techniques, and treatments to keep our readers informed and engaged.

View all posts by Catherine

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Director, Perfect Skin Studio

Dr. Sabrina Shah-Desai

With over 24 years of experience in both surgical and non-surgical procedures, Dr. Sabrina Shah-Desai is widely acknowledged as one of the most trusted and experienced practitioners in the UK. Her expertise, extensive training & compassionate approach have earned her the reputation as the preferred choice for patients seeking top-tier cosmetic treatments.

Dedicated to enhancing each patient’s natural beauty and instilling confidence at every age, Dr. Sabrina and her team customise treatment plans to achieve the best possible outcomes for each individual.

Dr. Sabrina’s excellence has been recognised through prestigious awards like the UK Safety in Beauty Diamond Award for “Aesthetic Doctor of the Year 2023” and the Aesthetic Award for “Highly Commended Consultant Surgeon 2022,” and “Best Consultant Surgeon 2021” & “Best Surgical Result 2021”. As a well-respected figure in aesthetics, she was honoured as one of the Global 100 Most Influential Aesthetic Practitioners of 2019 by the My Face My Body Awards.