Polynucleotides Side Effects: Know Before Your Treatment

In the ever-changing world of aesthetic and regenerative medicine, polynucleotide injections have emerged in the spotlight for their ability to rejuvenate the skin, improve skin texture, and stimulate intrinsic repair. However, as with any treatment, knowing the polynucleotide side effects [related to the procedure] is a crucial part of the process that must be fully understood before consenting to treatment. 

Whether the goal is to improve skin hydration, pliability, or smoothness, understanding the polynucleotide injection side effects will support an informed choice.

The goal of this article is to review what polynucleotides are, how they work, and, most importantly, the side effects—immediate and potential chronic impacts. We will also look at real-world knowledge from people who have received treatment in clinics, including clinics offering polynucleotides London services.

What are Polynucleotides?

Polynucleotides are biocompatible molecules from DNA fragments originating from fish sperm [salmon or trout], as they are the closest DNA to that of human DNA. Injecting polynucleotides into the skin stimulates repair of underlying tissues, improves hydration and promotes collagen deposition. Therefore, they are ideal for skin laxity due to hydrogel, scarring, and aging.

However, as with all treatments that penetrate the skin or bio-stimulate tissues, we must all understand the side effects of polynucleotide injections. 

Common Polynucleotide Side Effects

We will start by looking at the typical polynucleotide side effects that are reported regularly:

1. Redness and Swelling

An injection side effect common to polynucleotide injections is temporary redness and swelling at the injection site. Redness or swelling usually resolves after approximately 24 to 48 hours and sometimes slightly longer with individuals who may have sensitive skin.

2. Bruising

Mild bruising is also possible, and it is a regular result of any injection. Bruising is likely caused by the needle going through small blood vessels. It is not a sign of an allergic reaction or that the product is defective.

3. Itching or Sensitivity

Some individuals may also report localised itching, sensitivity, or tenderness soon after the treatment. Like redness and swelling, this polynucleotide side effect may go away on its own within a few days and is also simply a part of your body’s natural response to the injection.

Less Common Polynucleotide Injection Side Effects

While rare, some polynucleotide injection side effects may warrant more attention:

1. Lumps or Nodules

A few patients report the formation of small lumps or nodules under the skin. These are usually due to uneven product distribution or incorrect injection technique and tend to dissolve with time or require gentle massage.

2. Allergic Reactions

Although highly unlikely due to the product’s biocompatible nature, allergic reactions are possible. Symptoms may include rashes, swelling, or more severe immune responses.

3. Skin Discolouration

Mild hyperpigmentation or hypopigmentation can occasionally occur, especially in individuals with darker skin tones or those prone to post-inflammatory pigmentation.

Polynucleotide Injection Side Effects: Long-Term Concerns

When discussing the long-term effects of polynucleotide injection, it’s important to note that there is currently limited research regarding adverse effects after prolonged use. Most clinical studies and anecdotal evidence suggests that polynucleotide side effects remain mild and temporary. However, continued use over extended periods may lead to:

1. Skin Sensitisation

Repeated exposure may cause the skin to become more sensitive over time, particularly if combined with other aesthetic treatments such as microneedling or laser therapy.

2. Dependency on Regular Treatments

Some users may experience a sense of ‘dependency’ on the treatment for maintaining results, leading to frequent top-ups that could increase cumulative polynucleotide injection side effects.

3. Unpredictable Outcomes in Combination Therapies

When polynucleotides are combined with other injectables or skincare treatments, the risk of unexpected interactions may slightly rise, though it is still uncommon.

Although the long-term side effects remain a topic of ongoing research, current insights suggest these concerns are minimal when the qualified professional administers the treatment. 

Should You Avoid Polynucleotide Injections?

While most people tolerate the treatment well, the following groups should exercise caution or avoid polynucleotide injections altogether:

• Individuals with active skin infections or open wounds at the treatment site
  
• Those with known allergies to fish or seafood (due to the source of polynucleotides)
  
• Pregnant or breastfeeding women (due to lack of safety data)
  
• People with autoimmune disorders or immunosuppressed individuals
  

Consultation with a medical professional is essential before undergoing the procedure to ensure minimal polynucleotide side effects.

Managing Polynucleotide Injection Side Effects

If you’re experiencing any of the polynucleotide injection side effects mentioned, here’s how you can manage them:

• Cold Compress: Applying a cold pack to the area can help reduce swelling and bruising.
  
• Hydration and Rest: Keeping your skin and body hydrated aids in quicker recovery.
  
• Avoid Heat and Makeup: For 24 hours post-treatment, avoid saunas, sun exposure, and applying makeup on the treated area.
  
• Follow Post-Treatment Advice: To reduce the risk of adverse reactions, always adhere to aftercare instructions provided by your clinician.
  

Real Experiences: Polynucleotides London Clinics

Clinics offering Polynucleotides London treatments often report high satisfaction rates with minimal downtime or complications. Patients frequently note improvements in skin texture, reduced fine lines, and a natural glow. However, even in these top-tier establishments, transparency about the side effects of polynucleotide injection is maintained to ensure client safety and confidence.

Final Thoughts

Polynucleotides offer a promising route to natural skin rejuvenation, with most patients experiencing only mild, short-term side effects. However, no treatment is entirely risk-free. By understanding both common and rare polynucleotide injection side effects, including potential long-term side effects, you can make a well-informed decision aligned with your skincare goals.

As the popularity of polynucleotide treatments grows, so does the importance of receiving care from experienced professionals who prioritise safety, precision, and transparency. Always ensure your provider performs a thorough consultation and explains the potential polynucleotide side effects before proceeding with any injection-based treatment.

FAQs

1. Are the side effects of polynucleotide injection common?

Yes, mild polynucleotide side effects like redness, swelling, and bruising are common and typically resolve within a few days.

2. What are the side effects of long-term polynucleotide injection?

Polynucleotide injection side effects long-term are rare but may include skin sensitisation or dependency on frequent treatments.

3. Can I be allergic to polynucleotides?

Allergic reactions are rare but possible, especially if you have fish allergies, as the polynucleotides are derived from marine DNA.

4. How long do side effects last after treatment?

Most polynucleotide injection side effects last between 24 and 72 hours, though this can vary based on skin sensitivity and aftercare.

5. Is it safe to combine polynucleotides with other treatments?
 

Yes, but combining treatments may increase polynucleotide side effects if they are not spaced properly. Always consult your practitioner first.